Subcellomics Creative Proteomics

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Exosomes can be designed to display specific ligands on their surface to target specific cells and can be loaded with different drugs that can be located on the membrane surface or carried within the exosome. Compared to lipid nanoparticles, these intracellular vesicles exhibit lower immunogenicity and significantly reduced toxicity, but with improved drug encapsulation and greater in vivo biodistribution. To further promote the development of exosome-based genes and drug delivery, Creative Proteomics provides a range of customized and inventive services and solutions, including exosome isolation and purification, exosome identification, exosome proteomics analysis, exosome metabolomics analysis and so on.

Fig. 1 mRNA-encapsulated exosomes.

Comparison of exosomes and liposomes in delivering therapeutic materials

Liposomes are the earliest nanoparticle delivery platform. Liposomes are generally small circular vesicles with hydrophilic nuclei, consisting of one (unilamellar) or more (multilamellar) phospholipid layers that facilitate uptake by cells via endocytosis or endocytosis-like mechanisms. Compared to liposomes and other synthetic nanocarriers, endogenous sources confer a large number of unique properties to exosomes in targeted delivery. However, for the application of exosomes as drug carriers, the endogenous origin may be a double-edged sword.

Comparison of exosomes and liposomes
The advantages of exosomes in drug delivery versus liposomesThe disadvantages of exosomes in drug delivery versus liposomes
Highly biocompatible vesiclesLow production efficiency
More stable in the body fluidLimited efficiency of cargo loading
Better targeting capacityTougher quality control
Have bioactive materials that may be therapeutically

We provide the following exosome-based gene and drug delivery solutions, including but not limited to:

1. Exosomes as drug carriers

Since their discovery, exosomes have been potentially used as drug carriers for various diseases and cancers due to their unique properties such as stability, tumor targeting, and biocompatibility. As natural carriers, exosomes have not only been utilized to deliver RNA and proteins but also for the delivery of therapeutic small molecules. Creative Proteomics proudly offers a range of exosome research and analytical services. Our capability can greatly promote the application of exosomes as carriers for various genes and drug delivery, including

  • Exosomes for ASO Delivery
  • Exosomes for siRNA Delivery
  • Exosomes for miRNA Delivery
  • Exosomes for mRNA Delivery
  • Exosomes for circRNA Delivery
  • Exosomes for Protein Delivery
  • Exosomes for Small Molecule Delivery

2. Exosome-based vaccine development

To further promote the development of exosome-based vaccines, Creative Proteomics provides a range of customized and innovative solutions. We are committed to maximizing the potential of exosomes as an important candidate for infectious disease vaccine and cancer vaccine development. We hope to meet our customers' specific requirements for projects at the preclinical stage.

Creative Proteomics is committed to a culture of continuous improvement, innovation, and world-class customer support. For years, based on knowledge and experience in exosome research and analysis, we have been offering sustainable innovative services and solutions at low maintenance costs according to our global customers' needs. Contact us or directly send us an inquiry. We look forward to providing services for your next project.

Reference

  1. Fu, Shengyang, et al. "Exosome engineering: Current progress in cargo loading and targeted delivery." NanoImpact 20 (2020): 100261.

* For Research Use Only. Not for use in diagnostic procedures.

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